Helper T Cell Diversity and Plasticity

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Helper T cell diversity and plasticity.

CD4(+) helper T cells play crucial roles for host defense and immune-mediated disease by their ability to differentiate into specialized subsets. These subsets attain restricted patterns of cytokine secretion and specific expression of master transcription factors in response to microbial pathogens. Classically, the various helper CD4(+) T cell subsets have been viewed as terminally differentia...

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Following activation by antigen, helper T cells differentiate into one of many effector phenotypes. Formulating mechanistic mathematical models combining regulatory networks at the transcriptional, translational and epigenetic level, we study how individual helper T cells may adopt their different phenotypes. For each cytokine phenotype, for example, T helper type 1 (Th1) and type 2 (Th2) cells...

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CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity

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Helper T-cell differentiation and plasticity: insights from epigenetics.

CD4(+) T cells have critical roles in orchestrating immune responses to diverse microbial pathogens. This is accomplished through the differentiation of CD4(+) T helper cells to specialized subsets in response to microbial pathogens, which evoke a distinct cytokine milieu. Signal transducer and activator of transcription family transcription factors sense these cytokines and they in turn regu...

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ژورنال

عنوان ژورنال: Circulation Journal

سال: 2014

ISSN: 1346-9843,1347-4820

DOI: 10.1253/circj.cj-14-1164